Summary

Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes.  It is integral to the regulation of iron and it assumes a central role in sustaining overall health. The measurement of ferritin levels in the blood affords valuable insights into an individual's health status.

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Overview

Ferritin is a protein abundant throughout the body in places such as the liver, spleen, and bone marrow. It has a crucial role in maintaining iron levels for efficient oxygen transfer to the tissues. Iron deficiency can result in anemia, which is accompanied by fatigue and weakness. Fortunately, this problem can be addressed with simple dietary modifications or iron supplements.^[1,2]

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What should you know about Ferritin?

Understanding ferritin's  diverse functions in the body is crucial. It stores iron and it has supporting functions like oxygen transport. Low ferritin levels may indicate iron deficiency, leading to fatigue and anemia. Optimal levels promote overall well-being, while high levels may suggest inflammation or iron overload. 

The recommended range can vary by gender, usually between 13-150 µg/l (micrograms per liter) for women and 30-400 µg/l for men.^[3]

There are several possible states of your blood test result:^[4]

Low Levels

Low ferritin levels signal an insufficient storage of iron within the body. This often points to iron deficiency, a condition with symptoms including fatigue, weakness, and anemia. Since ferritin plays a crucial role in storing iron for essential functions like oxygen transport, low levels can impair these processes and affect an overall well-being.

Optimal Levels

Optimal ferritin levels reflect a healthy balance of iron storage in the body. Within the normal range, ferritin supports general well-being and ensures a steady supply of iron for vital functions.

High Levels

High ferritin levels can signify iron overload, potentially leading to organ damage over time. Alternatively, it may serve as a marker for inflammatory conditions, where the body's response triggers an increase in ferritin. If high levels are detected, it is crucial to consult a healthcare provider promptly for a thorough evaluation.

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Genetics

Some individuals may have a predisposition to higher or lower levels.^[5] 

Genetic variants in certain genes, such as the HFE gene, have been found to influence ferritin levels. For example, the G-allele of rs1800562 in the HFE gene has been associated with lower iron stores, while the C-allele of rs179945 in the same gene is associated with lower iron stores in men. Additionally, variants in other genes like TMPRSS6 and BTBD9 have also been found to affect ferritin levels.^[6]

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Recommendations

If your Ferritin levels are not within the optimal range, there are several recommendations:^[4,7]

• Regular Monitoring: Schedule regular blood tests to monitor ferritin levels, especially if you have a history of iron-related issues or conditions affecting inflammation.
• Balanced Diet: Maintain a well-balanced diet that includes a variety of nutrient-dense foods, ensuring sufficient intake of iron and other essential nutrients. Don't forget to consume vitamin C as well, as it helps to absorb iron from the intestine.
• Hydration: Stay adequately hydrated, as water plays a role in various physiological processes, including iron absorption.
• Supplementation under Guidance: Consider iron supplements only under the guidance of a healthcare professional to prevent potential adverse effects.
• Regular Exercise: Incorporate regular physical activity into your routine, as it can contribute to overall well-being and may positively influence iron metabolism.
• Collaborate with Healthcare Professionals: Consult with healthcare professionals for personalized advice, especially if there are concerns about ferritin levels.

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The information and tests provided on our website are for educational purposes only and are not a substitute for professional medical advice. Always consult your physician before making any decisions regarding your health. Our tests are not intended to diagnose or treat disease. Individual results may vary and should be consulted with your general practitioner or specialist.