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Polygenic score
Influential genes: ARID1A
ARID1A gene has been linked to the pathogenesis of various cancer types, including endometrial cancer.
Endometrial cancers are the most common cancers of the female reproductive tract. Most are hormone-depended arising on the base of high amounts of unopposed estrogen as seen around menopause (no counter acting progesterone). These tumors typically have a good prognosis. Hormone-independent neoplasms tend to have a genetic background (e.g., TP53 mutations).
Besides genetic mutations, the following factors increase your likelihood of getting this cancer: Early first period, late menopause, polycystic ovary syndrome, not having had kids, no breastfeeding, the use of tamoxifen or estrogen-only hormone therapy, obesity, high age, estrogen producing tumors.
Taking oral contraceptives for more than 10 years reduces your risk for endometrial cancer by 50 % (note: oral contraceptives are associated with other health issues). Having had breastfed children, as well as following a healthy diet, doing regular exercise, and maintaining a normal BMI reduces your too. Should you notice heavy, prolonged and/or irregular vaginal bleeding and discharge you should consult your gynecologist early.
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Continue to ShopTaking oral contraceptives for more than 10 years reduces your risk for endometrial cancer by 50 % (note: oral contraceptives are associated with other health issues). Having had breastfed children, as well as following a healthy diet, doing regular exercise, and maintaining a normal BMI reduces your too. Should you notice heavy, prolonged and/or irregular vaginal bleeding and discharge you should consult your gynecologist early.
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